منابع مشابه
Metabolism of clozapine by cDNA-expressed human cytochrome P450 enzymes.
The metabolism of clozapine was studied in vitro using cDNA-expressed human cytochrome P450 (CYP) enzymes 1A2, 3A4, 2C9, 2C19, 2D6, and 2E1. CYP1A2, 3A4, 2C9, 2C19, and 2D6 were able to N-demethylate clozapine. N-Oxide formation was exclusively catalyzed by CYP3A4. CYP2E1 did not metabolize clozapine. With regard to quantitative relationships, CYP1A2, 2C9, 2C19, and 2D6 displayed KM values rang...
متن کاملClozapine rechallenge following clozapine-induced pericarditis.
To the Editor: There are many reports describing the development of myocarditis and cardiomyopathy following treatment with clozapine. Fewer reports exist about the development of pericarditis, and reports of successful rechallenges with clozapine following the development of pericarditis are particularly rare. We report the case of a patient successfully resumed on clozapine treatment followin...
متن کاملRelation of blood counts during clozapine treatment to serum concentrations of clozapine and nor-clozapine.
OBJECTIVE To determine the relation between serum clozapine and nor-clozapine levels and blood cell counts during clozapine treatment. METHOD We undertook a prospective longitudinal study of 37 consecutive patients with a diagnosis of schizophrenia treated with clozapine. We obtained informed consent and then determined serum concentrations of clozapine and nor-clozapine weekly. Clozapine was...
متن کاملClozapine alone versus clozapine and risperidone for refractory schizophrenia.
BACKGROUND The treatment of schizophrenia with multiple antipsychotic drugs is common, but the benefits and risks are not known. METHODS In a randomized, double-blind study, we evaluated patients with schizophrenia and a poor response to treatment with clozapine. The patients continued to take clozapine and were randomly assigned to receive eight weeks of daily augmentation with 3 mg of rispe...
متن کاملDiabetic ketoacidosis and clozapine.
1 Ring J, Messmer K. Incidence and severity of anaphylactoid reactions to colloid volume substitutes. Lancet 1977;1:466-9. 2 Laxenaire MC, Charpentier C, Feldman L. [Anaphylactoid reactions to colloid plasma substitutes: incidence, risk factors, mechanisms. A French multicentre prospective study] (French). Ann FrAnesth Reanim 1994;13:301-10. 3 Watkins J, Wild G, Appleyard TN, Hardy G. Complemen...
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ژورنال
عنوان ژورنال: British Journal of Psychiatry
سال: 1998
ISSN: 0007-1250,1472-1465
DOI: 10.1192/bjp.173.1.87a